Why we think it’s important 

This research is important because it assesses the potential benefits and harms of cannabinoids in reducing symptoms like spasticity and chronic neuropathic pain in people with MS. 


For people dealing with multiple sclerosis (MS), spasticity and chronic neuropathic pain are two major hurdles. These symptoms get worse as the disease progresses, making daily life a real struggle. Unfortunately, the medications available often fall short or aren’t easy to tolerate. That’s where cannabinoids, like those found in cannabis, come into play. Researchers are exploring whether they could offer relief to people with MS. A recent study, called “Cannabis and Cannabinoids for Symptomatic Treatment for People with Multiple Sclerosis,” did a deep dive into whether these compounds can help. Let’s break down the study’s findings and what they mean. 

Digging for Info 

The research team did a thorough search, combing through databases and studies up until December 2021. They didn’t want to miss a thing, so they also checked the reference lists of other studies and reviews. 

Who’s In and Who’s Out? 

They focused on studies that used a randomized approach, looking at different types of cannabinoids, whether from herbal cannabis, synthetic sources, or other forms. The key was how these cannabinoids affected adults with MS. 

The Lowdown 

They studied 25 trials, involving over 3,700 participants, with nearly half of them using cannabinoids. These trials ranged from 3 to 48 weeks and tested various forms of cannabinoids, like nabiximols, synthetic versions, and even inhaled herbal cannabis, all compared to placebos. There are also eight ongoing studies in this field. 

Key Takeaways 

Spasticity: Nabiximols seemed to help reduce spasticity in people with MS. It was about 2.5 times more likely to provide relief compared to a placebo. This finding is pretty solid. 

Chronic Pain: Unfortunately, there wasn’t enough data on whether cannabinoids can ease chronic neuropathic pain. The evidence was pretty weak here. 

Side Effects: Cannabinoids did lead to slightly more people discontinuing treatment compared to placebos, but it wasn’t a huge difference. 

What Really Matters 

Feeling Better: Cannabinoids appeared to make people feel better about their health, with evidence leaning toward this improvement. 

Quality of Life: Cannabinoids didn’t seem to have a major impact on overall quality of life. 

Safety: They didn’t find a significant difference in serious side effects between those taking cannabinoids and those on placebos. 

Nervous and Psychiatric Side Effects: There was a slightly higher risk of nervous system and psychiatric issues with cannabinoids, but it wasn’t a slam dunk. 

Tolerance: The jury’s still out on whether cannabinoids lead to drug tolerance. 

In a Nutshell 

All things considered, nabiximols might help ease spasticity in the short term for people with MS. But when it comes to chronic pain and overall quality of life, cannabinoids don’t have a clear win. There is a bit of an increase in side effects, especially in the nervous and psychiatric areas, but it’s not a massive difference. This study reminds us that more research is needed to fully understand how cannabinoids can help with MS symptoms, especially for pain relief. If you’re thinking about using cannabinoids to manage your MS symptoms, it’s essential to talk to your healthcare provider. They can help you weigh the potential benefits against the risks and uncertainties. And remember, we need longer-term studies to get a clearer picture of how cannabinoids fit into the MS symptom management puzzle. 


“Cannabis and cannabinoids for symptomatic treatment for people with multiple sclerosis.” (G. Filippini, et al., Cochrane Database Syst Rev, 2022)